Rock Solid X is
based on peer reviewed clinical trials and studies:
Rock Solid X is
based on peer reviewed clinical trials and studies:
L-Arginine and L-Citruline
1. Moncada, S., & Higgs, A. (1993). The L-arginine-nitric oxide pathway. New England Journal of Medicine, 329(27), 2002-2012.
· This foundational paper on the L-arginine-nitric oxide pathway is relevant because L-Citrulline is converted to L-arginine in the body, which can then increase nitric oxide production.
2. Stanislavov, R., & Nikolova, V. (2003). Treatment of erectile dysfunction with pycnogenol and L-arginine. Journal of Sex & Marital Therapy, 29(3), 207-213.
· This study investigated the efficacy of L-arginine combined with pycnogenol in treating ED. Over a period of three months, men with ED were given L-arginine (3x 500 mg/day) for the first month. For the second month, they continued with L-arginine and added pycnogenol (40 mg/day). In the third month, the dose of pycnogenol was increased. The combination of L-arginine and pycnogenol significantly improved erectile function.
3. Romero, M. J., Platt, D. H., Caldwell, R. B., & Caldwell, R. W. (2006). Therapeutic use of citrulline in cardiovascular disease. Cardiovascular drug reviews, 24(3-4), 275-290.
· This review touches on the potential therapeutic uses of L-Citrulline in various cardiovascular conditions, which can be related to its potential effects on ED given the vascular nature of the condition.
4. Shibuya, Y., Kuhara, T., Adachi, H., & Yoshida, Y. (2008). Effects of L-arginine and L-citrulline oral supplements on blood pressure. Heart and vessels, 23(2), 136-142.
· While this study primarily focused on blood pressure, it provides insight into the vasodilatory effects of L-Citrulline, which can be related to ED.
5. Schwedhelm, E., Maas, R., Freese, R., Jung, D., Lukacs, Z., Jambrecina, A., ... & Böger, R. H. (2008). Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. British journal of clinical pharmacology, 65(1), 51-59.
· This study looked at the pharmacokinetics of L-Citrulline and its conversion to L-arginine, which is directly related to nitric oxide production and, by extension, potential effects on ED.
6. Sureda, A., Córdova, A., Ferrer, M. D., Pérez, G., Tur, J. A., & Pons, A. (2010). L-citrulline-malate influence over branched chain amino acid utilization during exercise. European journal of applied physiology, 110(2), 341-351.
· This study is more about exercise performance, but it's relevant because it touches on the mechanisms of L-Citrulline in the body, which can have implications for ED.
7. Cormio, L., De Siati, M., Lorusso, F., Selvaggio, O., Mirabella, L., Sanguedolce, F., & Carrieri, G. (2011). Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Urology, 77(1), 119-122.
· This study examined the effects of L-citrulline supplementation on men with mild ED. The researchers found that L-citrulline supplementation led to a significant improvement in erection hardness compared to placebo.
8. Barassi, A., Corsi Romanelli, M. M., Pezzilli, R., Damele, C. A. L., Vaccalluzzo, L., Goi, G., ... & Melzi dʼEril, G. V. (2018). Levels of L-arginine and L-citrulline in patients with erectile dysfunction of different etiology. Andrology, 6(2), 323-328.
· While this study primarily focused on the levels of L-arginine and L-citrulline in patients with ED, it also highlighted the potential therapeutic role of these amino acids in ED treatment. The research indicated that there were differences in the levels of these amino acids based on the etiology of the ED.
9. Rhim, H. C., Kim, M. S., Park, Y. J., Choi, W. S., Park, H. K., Kim, H. G., Kim, A., & Paick, S. H. (2019). The Potential Role of Arginine Supplements on Erectile Dysfunction: A Systemic Review and Meta-Analysis. The Journal of Sexual Medicine, 16(2), 223-234.
· This systematic review and meta-analysis examined the efficacy of arginine supplements in treating erectile dysfunction (ED). The study analyzed 10 randomized controlled trials involving 540 patients with ED. The results showed that arginine supplements, with dosages ranging from 1,500 to 5,000 mg, significantly improved ED compared to placebo or no treatment (odds ratios, 3.37 [1.29, 8.77], P = .01, I2 = 44). Arginine supplementation also led to significant improvements in the IIEF subdomain scores of overall satisfaction, intercourse satisfaction, orgasmic function, and erectile function.
Korean Ginseng (Panax Ginseng)
1. Choi, H. K., Seong, D. H., & Rha, K. H. (1995). Clinical efficacy of Korean red ginseng for erectile dysfunction. International Journal of Impotence Research, 7(3), 181-186.
· This study directly evaluated the clinical efficacy of Korean red ginseng for impotence, suggesting it as an alternative remedy.
2. Hong, B., Ji, Y. H., Hong, J. H., Nam, K. Y., & Ahn, T. Y. (2002). A double-blind crossover study evaluating the efficacy of Korean red ginseng in patients with erectile dysfunction: a preliminary report. Journal of Urology, 168(5), 2070-2073.
· This study directly evaluated the efficacy of Korean red ginseng in patients with ED and found it to be an effective alternative treatment.
3. Jang, D. J., Lee, M. S., Shin, B. C., Lee, Y. C., & Ernst, E. (2008). Red ginseng for treating erectile dysfunction: a systematic review. British Journal of Clinical Pharmacology, 66(4), 444-450.
· While this systematic review of randomized clinical trials (RCTs) primarily focused on the overall effectiveness of red ginseng, it suggested evidence for the effectiveness of red ginseng in the treatment of erectile dysfunction.
4. Kim, T. H., Jeon, S. H., Hahn, E. J., Paek, K. Y., Park, J. K., Youn, N. Y., & Lee, H. L. (2009). Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction. Asian Journal of Andrology, 11(3), 356-361.
· This study explored the effects of tissue-cultured mountain ginseng extract on male patients with ED and found improvements in erectile function.
5. Choi, Y. D., Park, C. W., Jang, J., Kim, S. H., Jeon, H. Y., Kim, W. G., ... & Ahn, T. Y. (2013). Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study. International Journal of Impotence Research, 25(2), 45-50.
· This multicenter study evaluated the effects of ginseng berry extract on sexual function in men with ED and found improvements in all domains of sexual function.
Tribulus Terrestris
1. Gauthaman, K., Adaikan, P. G., & Prasad, R. N. (2002). Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats. Life sciences, 71(12), 1385-1396.
· The research indicated that Tribulus terrestris extract, particularly its active component protodioscin, has aphrodisiac properties, which may be beneficial for ED.
2. Do, J., Choi, S., Choi, J., & Hyun, J. S. (2008). Effects and mechanism of action of a Tribulus terrestris extract on penile erection. Korean Journal of Urology, 49(3), 265-271.
· This study explored the effects and mechanisms of action of a Tribulus terrestris extract on penile erection. The findings suggested that the extract might enhance penile erection by increasing the release of nitric oxide.
3. Kamenov, Z., Fileva, S., Kalinov, K., & Jannini, E. A. (2009). Evaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction—A prospective, randomized, double-blind, placebo-controlled clinical trial. Maturitas, 63(4), 323-327.
· This clinical trial evaluated the efficacy and safety of Tribulus terrestris in men with sexual dysfunction. The results indicated that Tribulus terrestris might be useful in mild to moderate cases of ED.
4. Santos, C. A., Reis, A. M., Asano, R. Y., Filho, B. O., Silva, A. S., & de Oliveira, R. V. (2014). Tribulus terrestris versus placebo in the treatment of erectile dysfunction: A prospective, randomized, double blind study. Acta Paulista de Enfermagem, 27(3), 221-226.
· In this randomized, double-blind study, Tribulus terrestris was compared to a placebo for the treatment of ED. The results suggested that Tribulus terrestris might have a positive effect on improving erectile function.
5. Neychev, V. K., & Mitev, V. I. (2016). Pro-sexual and androgen enhancing effects of Tribulus terrestris L.: Fact or Fiction. Journal of ethnopharmacology, 179, 345-355.
· This review article critically assessed the available evidence on the pro-sexual and androgen-enhancing effects of Tribulus terrestris. The authors concluded that the plant might improve sexual function in humans.
Maca
1. Gonzales, G. F., Córdova, A., Vega, K., Chung, A., Villena, A., & Góñez, C. (2002). Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Andrologia, 34(6), 367-372.
· This study found that Maca improved sexual desire in healthy adult men after 8 weeks of treatment, but this effect was not related to changes in serum testosterone levels.
2. Gonzales, G. F., Córdova, A., Vega, K., Chung, A., Villena, A., Góñez, C., & Castillo, S. (2003). Effect of Lepidium meyenii (Maca) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Urology, 61(2), 395-399.
· This study further confirmed the findings of the previous study, suggesting that Maca can improve sexual desire without affecting serum testosterone levels.
3. Dording, C. M., Fisher, L., Papakostas, G., Farabaugh, A., Sonawalla, S., Fava, M., & Mischoulon, D. (2008). A double-blind, randomized, pilot dose-finding study of maca root (L. meyenii) for the management of SSRI-induced sexual dysfunction. CNS Neuroscience & Therapeutics, 14(3), 182-191.
· This study evaluated Maca's potential to manage sexual dysfunction induced by SSRIs (a class of antidepressants). The results suggested that Maca might have benefits for this specific type of sexual dysfunction.
4. Zenico, T., Cicero, A. F. G., Valmorri, L., Mercuriali, M., & Bercovich, E. (2009). Subjective effects of Lepidium meyenii (Maca) extract on well-being and sexual performances in patients with mild erectile dysfunction: a randomised, double-blind clinical trial. Andrologia, 41(2), 95-99.
· In this study, patients with mild ED showed a significant improvement in subjective perception of general and sexual well-being when treated with Maca.
5. Stone, M., Ibarra, A., Roller, M., Zangara, A., & Stevenson, E. (2009). A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen. Journal of Ethnopharmacology, 126(3), 574-576.
· This study found that Maca supplementation improved both physical performance and sexual desire in male athletes.
Cordyceps
1. Ng, T. B., & Wang, H. X. (2005). Pharmacological actions of Cordyceps, a prized folk medicine. Journal of Pharmacy and Pharmacology, 57(12), 1509-1519.
· This review article summarizes the various pharmacological actions of Cordyceps. Among the discussed benefits, the potential effects on sexual function and ED are mentioned.
2. Luo, J., Dong, B., Wang, K., Cai, S., Liu, T., & Cheng, W. (2009). Antagonistic effects of two herbs in Zuotai pill, a traditional Tibetan medicine formula, on mitochondrial respiration. Journal of ethnopharmacology, 121(3), 474-479.
· This study explored the effects of Cordyceps on mitochondrial respiration, which can indirectly influence energy production and stamina. While not directly focused on ED, the results suggest that Cordyceps might improve physical stamina, which could be beneficial for sexual function.
3. Chen, S., Li, Z., Krochmal, R., Abrazado, M., Kim, W., & Cooper, C. B. (2010). Effect of Cs-4® (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial. The Journal of Alternative and Complementary Medicine, 16(5), 585-590.
· While this study primarily focused on the effects of Cordyceps on exercise performance in older subjects, the results might have implications for ED. Improved physical performance and stamina could indirectly benefit sexual function.
4. Zhao, J., Xie, J., Wang, L. Y., & Li, S. P. (2014). Advanced development in chemical analysis of Cordyceps. Journal of pharmaceutical and biomedical analysis, 87, 271-289.
· This comprehensive review provides an overview of the chemical constituents found in Cordyceps and their potential pharmacological effects. The study suggests that some of these constituents may have potential benefits for ED.
Guarana
1. Kennedy, D. O., Haskell, C. F., Wesnes, K. A., & Scholey, A. B. (2004). Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng. Pharmacology Biochemistry and Behavior, 79(3), 401-411.
· This study explored the cognitive benefits of guarana extract and found that it can improve cognitive performance.
2. Boone, S. A., Shields, K. M. (2005). Treating fatigue. Journal of the American Pharmacists Association, 45(4), 526-537.
· This review article discussed various treatments for fatigue, including guarana. It highlighted the stimulant properties of guarana and its potential benefits in reducing fatigue and improving alertness.
3. Haskell, C. F., Kennedy, D. O., Wesnes, K. A., Milne, A. L., & Scholey, A. B. (2007). A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guaraná in humans. Journal of Psychopharmacology, 21(1), 65-70.
· This research evaluated the acute behavioral effects of guarana in humans. The results indicated that guarana could improve secondary memory performance and increase alertness and contentment levels..
4. Moustakas, D., Mezzio, M., Rodriguez, B. R., Constable, M. A., Mulligan, M. E., & Voura, E. B. (2015). Guarana provides additional stimulation over caffeine alone in the planarian model. PLOS ONE, 10(4), e0123310.
· This study compared the stimulating effects of guarana to caffeine. It was found that guarana might offer more stimulation than caffeine alone.
Guarana is renowned for its stimulating properties, largely attributed to its caffeine content. While caffeine and other stimulants may not directly influence sexual function, they can enhance alertness and combat fatigue, potentially giving an indirect boost to libido and sexual desire